Clinical Research Experience
Over the years, iCTS has supported a range of clinical research studies across Africa, including cardiovascular, hypertension, maternal health and community-based research programmes.
Comparison of Three Anti-Hypertensive Combination Therapies in Black Patients
Study Type: Randomized controlled trial
10 sites across 6 sub-Saharan African countries: Cameroon, Kenya, Mozambique, Nigeria, South Africa, and Uganda.
Observational Program to assess Blood Pressure Control and Tolerability of Perindopril-Amlodipine Fixed-Dose Combination, with or without Diuretics in Nigeria (13-City Hypertension Study)
Study Type: Observational study
Observational study conducted across 13 cities in Nigeria to evaluate blood pressure control and tolerability.
The Efficacy and Tolerability of Highly Selective Beta-1 Agent Nebivolol in Hypertensive Black Patients Residing in sub-Saharan Africa: A Pilot Study
Study Type: Pilot study
Pilot study assessing the efficacy and safety of Nebivolol in hypertensive black patients in sub-Saharan Africa.
The Investigation of the Management of Pericarditis (IMP) Trial
Study Type: Randomized controlled trial
Investigation into the optimal management strategies for pericarditis in clinical settings.
The evidence-based treatment of hypertensive heart failure in sub-Saharan Africa: A feasibility study
Study Type: Feasibility study
Feasibility study examining the implementation of evidence-based treatment protocols for hypertensive heart failure.
Clinical Outcomes in 3343 Children and Adults with Rheumatic Heart Disease from 14 Low and Middle Income Countries: 2-Year Follow-up of the Global Rheumatic Heart Disease Registry (the REMEDY study)
Study Type: Prospective registry study
Longitudinal follow-up study tracking clinical outcomes in patients with rheumatic heart disease across 14 countries.
Bi treatment with hydralazine/nitrates vs placebo in Africans admitted with acute Heart Failure (BA-HEF): BA-HEF
Study Type: Randomized placebo-controlled trial
Randomized trial comparing the efficacy of hydralazine/nitrates versus placebo in acute heart failure in African patients.
Evaluation of a triple single-pill combination (triple pill)-based treatment protocol compared to the Nigeria hypertension treatment protocol for improving BP control in Nigeria (VERONICA Trial)
Study Type: Randomized controlled trial
Comparative study evaluating the effectiveness of triple-pill regimen versus standard treatment protocols in Nigeria.
GMRx2-PCT trial
Study Type: Randomized controlled trial
Clinical trial focused on the implementation and outcomes of a specific treatment protocol (GMRx2-PCT).
Transforming Hypertension Management in Nigeria- Quasi experimental
Study Type: Quasi-experimental study
Quasi-experimental study aimed at transforming hypertension management practices in Nigeria through innovative interventions.
Managing Hypertension among People Living with HIV: an Integrated Model (MAP-IT)- Step wedge
Study Type: Stepped-wedge cluster randomized trial
Step-wedge study integrating hypertension management into HIV care services to improve cardiovascular outcomes.
Enhancing Intergenerational HeAlth in Nigeria: Peripartum as Critical Life StaGe for CardioVascular Health (ENHANCE-CVH)- Cluster randomized trial
Study Type: Cluster randomized trial
Cluster randomized trial focusing on the peripartum period as a critical window for cardiovascular health interventions.
ADdressing Hypertension CaRe in Africa- Step wedge
Study Type: Stepped-wedge cluster randomized trial
Step-wedge study aimed at improving hypertension care pathways across primary care settings in Africa.
Evaluation of a triple single-pill combination (triple pill)-based treatment protocol compared to the Nigeria hypertension treatment protocol for improving BP control in Nigeria (VERONICA Trial)- EXTENSION
Study Type: Extension study
Extension study continuing the evaluation of the triple-pill regimen in Nigeria, focusing on long-term adherence and outcomes.
Improving Maternal Outcomes through the Aspirin Implementation in Maternity (AIM) Bundle in Nigeria- Clinical aspect
Study Type: Clinical implementation study
Clinical implementation study evaluating the impact of the AIM bundle on maternal outcomes in Nigeria.
ACTION Study- Potassium enriched salt: Trial of Potassium enriched salt on top of GMRX2 to test effect on the level of potassium
Study Type: Randomized clinical trial
Randomized trial assessing the impact of potassium-enriched salt on potassium levels when added to the GMRX2 regimen.
Veronica-Amiloride: Trial of the effect of Amiloride on top of GMRX2 on levels of potassium
Study Type: Randomized clinical trial
Trial investigating the effect of adding Amiloride to the GMRX2 regimen on potassium levels in patients.